LAMA3

Across TCGA pan-cancer cohorts, LAMA3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated LAMA3 data layer compared with 27 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher LAMA3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LAMA3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

LUAD, PDAC, and GBM are the cancer types where LAMA3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.777	0.983	.001	52	view →
PDAC	OS	Tertile	All	0.276	0.528	.003	33	view →
GBM	DFS	Median	All	0.126	0.608	.022	16	view →
UCEC	DFS	Tertile	III,IV	1.000	0.503	.026	12	view →
CCRCC	OS	Median	IV	0.123	0.785	.009	12	view →
LSCC	OS	Tertile	II,III,IV	0.821	1.000	.036	4	view →
HNSC	DFS	Median	III,IV	1.000	0.939	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

LAMA3–LUAD (DFS)

Open the LUAD breakdown →