LAMA3

Across TCGA pan-cancer cohorts, LAMA3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of LAMA3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LAMA3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LAMA3 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

HNSC, LIHC, and KIRP are the cancer types where LAMA3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LAMA3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+4.263	<.001	12	view →
LIHC	Male	II,III,IV	+2.196	<.001	9	view →
KIRP	All	III,IV	+2.007	<.001	9	view →
COAD	All	All	−0.687	.002	7	view →
BRCA	Female	All	−1.998	<.001	6	view →
STAD	Male	All	+1.596	.002	6	view →
KIRC	Male	All	+0.785	<.001	6	view →
LUAD	Female	All	−1.851	<.001	5	view →
UCEC	All	All	−1.196	<.001	4	view →
CHOL	All	All	+2.670	<.001	3	view →
PAAD	All	All	+3.497	.007	2	view →
PRAD	All	All	−0.626	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

LAMA3–HNSC

Open the HNSC breakdown →