LAMA3

Across TCGA patient cohorts, LAMA3 mutation is significantly associated with the total protein of many other genes, with 78 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAMA3-associated genes across cancer lineages are ASNS, FoxM1, and PCNA. Each is linked with LAMA3 in more than 4 cancer types. Because this analysis shows association rather than direction, both LAMA3-to-partner and partner-to-LAMA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by LAMA3-low versus LAMA3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMA3→partner) and Y-score (partner→LAMA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.357	+1.330	.009	.045	3	5
UCEC	FoxM1 →	+0.167	+1.514	.009	<.001	3	4
COAD	PCNA →	+0.270	+1.686	.001	.013	3	4
COAD	Caspase-7-cleavedD198 →	+0.909	+2.700	<.001	.005	3	4
COAD	Smad4 →	+0.120	+3.700	.008	.001	3	4
COAD	Cyclin-E1 →	+0.193	+3.459	.026	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

ASNS by LAMA3 expression — COAD

Explore this box plot interactively →