LAMA3

Across TCGA cell cohorts, LAMA3 mutation is significantly associated with the RNA expression of many other genes, with 1,154 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LAMA3-associated genes across cancer lineages are RAD21, UNC119B, and SARS1. Each is linked with LAMA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both LAMA3-to-partner and partner-to-LAMA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD21 grouped by LAMA3-low versus LAMA3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAMA3→partner) and Y-score (partner→LAMA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RAD21 →	+0.889	+3.115	.002	.009	3	3
BLOOD_Leukemia	UNC119B →	+0.742	+3.199	.001	.007	3	3
LARGE_INTESTINE	SARS1 →	+0.713	+2.807	<.001	<.001	3	3
LARGE_INTESTINE	HINT3 →	+0.636	+2.043	<.001	.001	3	3
LARGE_INTESTINE	MRPS5 →	+0.287	+3.237	.009	.003	3	3
LUNG_NSCLC_LUAD	XCL2 →	+0.159	+3.095	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,154 associations by consensus.

RAD21 by LAMA3 expression — BLOOD_Leukemia

Explore this box plot interactively →