LAG3

Across TCGA patient cohorts, LAG3 protein abundance is significantly associated with the RNA expression of many other genes, with 1,176 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LAG3-associated genes across cancer lineages are PDE12, MIR556, and HACD3. Each is linked with LAG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAG3-to-partner and partner-to-LAG3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LAG3 versus PDE12 in HNSC, with a Pearson correlation of -0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAG3→partner) and Y-score (partner→LAG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PDE12 →	-0.585	-0.523	.005	.006	3	2
HNSC	MIR556 →	-2.388	-0.665	<.001	.001	3	2
LSCC	HACD3 →	-1.018	-0.797	.001	.003	3	2
LUAD	USP14 →	+0.625	+0.844	.007	.002	3	1
LUAD	PPFIBP1 →	+0.631	+0.961	.002	.008	3	1
LUAD	CCN6 →	-0.287	-0.769	.006	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,176 associations by consensus.

LAG3 vs PDE12 — HNSC

Explore this scatter interactively →