LAG3

Across TCGA patient cohorts, LAG3 mutation is significantly associated with the RNA expression of many other genes, with 1,111 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAG3-associated genes across cancer lineages are MIR3168, UBE2V2P1, and PNMA6A. Each is linked with LAG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAG3-to-partner and partner-to-LAG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3168 grouped by LAG3-low versus LAG3-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAG3→partner) and Y-score (partner→LAG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MIR3168 →	+0.703	+5.219	<.001	.006	3	2
CESC	UBE2V2P1 →	+0.159	+4.779	.007	.001	3	2
UCEC	PNMA6A →	-1.090	-3.584	<.001	.002	3	2
SKCM	RN7SL51P →	+0.046	+2.574	.009	.007	3	2
UCEC	ELMO2P1 →	+0.117	+1.709	.001	.006	3	2
BRCA	RN7SKP65 →	+0.215	+5.288	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,111 associations by consensus.

MIR3168 by LAG3 expression — READ

Explore this box plot interactively →