LACTB

Across TCGA patient cohorts, LACTB mutation is significantly associated with the RNA expression of many other genes, with 3,379 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LACTB-associated genes across cancer lineages are IGHD5-12, MTCO3P16, and RNU4-58P. Each is linked with LACTB in more than 1 cancer types. Because this analysis shows association rather than direction, both LACTB-to-partner and partner-to-LACTB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD5-12 grouped by LACTB-low versus LACTB-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LACTB→partner) and Y-score (partner→LACTB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IGHD5-12 →	+1.181	+5.145	<.001	.007	3	2
COAD	MTCO3P16 →	+0.199	+5.893	<.001	.002	3	2
UCEC	RNU4-58P →	+0.146	+2.285	.009	.005	3	2
UCEC	IGHD3-9 →	+1.672	+2.727	<.001	<.001	3	2
UCEC	RNU6-718P →	+0.110	+3.140	.003	.004	3	2
UCEC	RNA5SP420 →	+0.475	+1.774	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,379 associations by consensus.

IGHD5-12 by LACTB expression — COAD

Explore this box plot interactively →