LACTB

Across TCGA cell cohorts, LACTB mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LACTB-associated genes across cancer lineages are OR1L3, FAM47C, and MSGN1. Each is linked with LACTB in more than 1 cancer types. Because this analysis shows association rather than direction, both LACTB-to-partner and partner-to-LACTB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by LACTB-low versus LACTB-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LACTB→partner) and Y-score (partner→LACTB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR1L3 →	+0.029	+5.415	<.001	.004	3	1
SKIN	FAM47C →	+0.006	+4.977	<.001	.007	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	PPP1R42 →	+0.084	+3.781	.006	.003	3	1
LARGE_INTESTINE	GLB1L3 →	+0.719	+3.453	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR1L3 by LACTB expression — SKIN

Explore this box plot interactively →