L3MBTL4

Across TCGA cell cohorts, L3MBTL4 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. CNS shows the largest number of these associations.

The most reproducible L3MBTL4-associated genes across cancer lineages are CXorf51A, PRND, and AQP12A. Each is linked with L3MBTL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both L3MBTL4-to-partner and partner-to-L3MBTL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CXorf51A grouped by L3MBTL4-low versus L3MBTL4-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L3MBTL4→partner) and Y-score (partner→L3MBTL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CXorf51A →	+0.076	+3.273	<.001	.004	3	2
BLOOD_Lymphoma	PRND →	+0.030	+3.353	.001	.002	3	2
CNS	AQP12A →	+0.047	+4.981	<.001	.008	3	2
OESOPHAGUS	NRSN1 →	+0.029	+3.906	<.001	.001	3	1
LARGE_INTESTINE	OR2V1 →	+0.042	+4.095	.004	.009	3	1
BREAST	CA5A →	+0.130	+3.657	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

CXorf51A by L3MBTL4 expression — OESOPHAGUS

Explore this box plot interactively →