L3MBTL4

Across TCGA cell cohorts, L3MBTL4 mutation is significantly associated with the mutation status of many other genes, with 1,863 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible L3MBTL4-associated genes across cancer lineages are IFI16, CDH12, and ZNF716. Each is linked with L3MBTL4 in more than 3 cancer types. Because this analysis shows association rather than direction, both L3MBTL4-to-partner and partner-to-L3MBTL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFI16 grouped by L3MBTL4-low versus L3MBTL4-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L3MBTL4→partner) and Y-score (partner→L3MBTL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	IFI16 →	+5.614	+5.044	.003	.003	1	4
LARGE_INTESTINE	CDH12 →	+2.284	+3.925	.005	.005	1	4
UPPER_AERODIGESTIVE_TRACT	ZNF716 →	+4.392	+4.954	.008	.008	1	4
LUNG_NSCLC_LUAD	RSPH6A →	+3.924	+5.063	.001	.001	1	3
CNS	GBE1 →	+5.614	+5.044	.003	.003	1	3
LUNG_NSCLC_LUAD	GNAI1 →	+4.339	+4.339	.009	.009	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,863 associations by consensus.

IFI16 by L3MBTL4 expression — CNS

Explore this box plot interactively →