L3MBTL4-AS1

Across TCGA pan-cancer cohorts, L3MBTL4-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated L3MBTL4-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher L3MBTL4-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated L3MBTL4-AS1 expression acts as an unfavorable survival marker, although some lineages such as DLBC and HNSC show a favorable association.

UVM, LGG, and DLBC are the cancer types where L3MBTL4-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.365	0.832	<.001	113	view →
LGG	DFS	Median	All	0.651	0.823	<.001	53	view →
DLBC	DFS	Median	II,III,IV	1.000	0.581	.002	50	view →
HNSC	DFS	Tertile	III,IV	0.539	0.307	<.001	50	view →
CESC	OS	Tertile	All	0.938	0.824	.008	30	view →
LAML	DFS	Tertile	All	0.276	0.653	<.001	28	view →
LUAD	DFS	Median	III,IV	0.630	0.255	.002	22	view →
COAD	OS	Median	III,IV	0.245	0.685	.004	13	view →
GBM	DFS	Quartile	All	0.214	0.493	.007	12	view →
KIRP	OS	Quartile	All	0.962	0.844	.012	11	view →
BLCA	OS	Quartile	All	0.389	0.615	.039	10	view →
ESCA	DFS	Tertile	II,III,IV	1.000	0.350	.013	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

L3MBTL4-AS1–UVM (OS)

Open the UVM breakdown →