L3MBTL4-AS1

Across TCGA pan-cancer cohorts, L3MBTL4-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of L3MBTL4-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where L3MBTL4-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types L3MBTL4-AS1 is over-expressed in tumor.

KIRC, KIRP, and HNSC are the cancer types where L3MBTL4-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in L3MBTL4-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.885	<.001	12	view →
KIRP	Male	All	+0.757	<.001	9	view →
HNSC	All	III,IV	+0.170	.001	7	view →
BRCA	Female	II,III,IV	+0.345	<.001	6	view →
LUAD	All	All	+0.308	.001	5	view →
LIHC	All	II,III,IV	+0.119	.012	4	view →
KICH	Female	All	+0.221	.010	2	view →
PRAD	All	All	+0.109	.002	2	view →
THCA	All	All	+0.095	.015	2	view →
CHOL	All	All	+0.213	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

L3MBTL4-AS1–KIRC

Open the KIRC breakdown →