L3MBTL3

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, L3MBTL3 mutation is significantly associated with the RNA expression of many other genes, with 1,740 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible L3MBTL3-associated genes across cancer lineages are HSBP1P1, MIR3612, and ROPN1B. Each is linked with L3MBTL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both L3MBTL3-to-partner and partner-to-L3MBTL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L3MBTL3→partner) and Y-score (partner→L3MBTL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LIHCHSBP1P1 →+0.277+5.447<.001.00532
PRADMIR3612 →+0.443+7.939<.001.00832
SKCMROPN1B →-0.849-2.668.005.00632
BRCATGIF2LX →+0.533+4.664<.001.00432
BRCAOR5AN1 →+0.114+5.324<.001.00332
BRCARNU6-497P →+0.268+4.971<.001.00532
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,740 associations by consensus.

Exploration