L3MBTL2-AS1

Across TCGA pan-cancer cohorts, L3MBTL2-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated L3MBTL2-AS1 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher L3MBTL2-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated L3MBTL2-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, HNSC, and ACC are the cancer types where L3MBTL2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.769	0.610	<.001	133	view →
HNSC	DFS	Median	IV	0.725	0.555	<.001	130	view →
ACC	DFS	Tertile	All	0.266	0.729	<.001	68	view →
UCS	DFS	Quartile	III,IV	0.581	0.096	.001	60	view →
KICH	DFS	Median	III,IV	0.373	1.000	.008	53	view →
LGG	OS	Tertile	All	0.852	0.943	<.001	32	view →
ESCA	OS	Tertile	All	0.798	0.603	.010	22	view →
CESC	OS	Tertile	IV	0.734	0.248	.006	22	view →
MESO	OS	Median	III,IV	0.781	0.301	.003	21	view →
LUSC	OS	Quartile	All	0.845	0.709	.003	17	view →
GBM	DFS	Quartile	All	0.156	0.407	.004	12	view →
READ	OS	Tertile	II,III,IV	0.933	0.422	.025	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

L3MBTL2-AS1–LUAD (OS)

Open the LUAD breakdown →