L3HYPDH

Across TCGA patient cohorts, L3HYPDH mutation is significantly associated with the RNA expression of many other genes, with 194 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible L3HYPDH-associated genes across cancer lineages are SEPTIN7P4, OR2G3, and MTND4P28. Each is linked with L3HYPDH in more than 2 cancer types. Because this analysis shows association rather than direction, both L3HYPDH-to-partner and partner-to-L3HYPDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPTIN7P4 grouped by L3HYPDH-low versus L3HYPDH-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L3HYPDH→partner) and Y-score (partner→L3HYPDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SEPTIN7P4 →	+0.144	+5.332	.004	.002	3	3
SKCM	OR2G3 →	+0.028	+4.385	.001	.008	3	2
SKCM	MTND4P28 →	+0.064	+4.884	<.001	.004	3	2
HNSC	LINC01066 →	+0.129	+5.822	<.001	.003	3	2
BLCA	RNU1-64P →	+0.363	+7.640	<.001	.009	3	2
UCEC	RNA5SP247 →	+0.662	+3.094	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 194 associations by consensus.

SEPTIN7P4 by L3HYPDH expression — COAD

Explore this box plot interactively →