L2HGDH

Across TCGA patient cohorts, L2HGDH RNA expression is significantly associated with the protein abundance of many other proteins, with 22,648 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible L2HGDH-associated proteins across cancer lineages are PPP4R3A, TRMT5, and ACIN1. Each is linked with L2HGDH in more than 8 cancer types. Because this analysis shows association rather than direction, both L2HGDH-to-partner and partner-to-L2HGDH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, L2HGDH versus PPP4R3A in LSCC, with a Pearson correlation of 0.66.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (L2HGDH→partner) and Y-score (partner→L2HGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PPP4R3A →	+0.366	+0.706	<.001	<.001	3	9
LSCC	TRMT5 →	+0.468	+0.733	<.001	<.001	3	9
HNSC	ACIN1 →	+0.231	+0.785	<.001	<.001	3	8
LSCC	UBR7 →	+0.365	+0.726	<.001	<.001	3	8
LSCC	SSRP1 →	+0.548	+0.732	<.001	<.001	3	8
LSCC	SUPT16H →	+0.517	+0.707	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,648 associations by consensus.

L2HGDH vs PPP4R3A — LSCC

Explore this scatter interactively →