L2HGDH

Across TCGA patient cohorts, L2HGDH mutation is significantly associated with the RNA expression of many other genes, with 1,151 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible L2HGDH-associated genes across cancer lineages are PSMD14P1, RGPD4-AS1, and RPL7L1P5. Each is linked with L2HGDH in more than 1 cancer types. Because this analysis shows association rather than direction, both L2HGDH-to-partner and partner-to-L2HGDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMD14P1 grouped by L2HGDH-low versus L2HGDH-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L2HGDH→partner) and Y-score (partner→L2HGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PSMD14P1 →	+0.064	+5.076	<.001	.001	3	2
SKCM	RGPD4-AS1 →	+0.025	+3.595	<.001	.002	3	2
LUAD	RPL7L1P5 →	+0.077	+4.372	.005	.007	3	2
COAD	RNU6-1242P →	+0.894	+5.017	<.001	.009	3	2
UCEC	RNA5SP113 →	+0.421	+3.003	<.001	.007	3	2
UCEC	SPCS3-AS1 →	+0.136	+2.031	.006	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,151 associations by consensus.

PSMD14P1 by L2HGDH expression — LUAD

Explore this box plot interactively →