L2HGDH

Across TCGA cell cohorts, L2HGDH mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible L2HGDH-associated genes across cancer lineages are RFX4, OR10W1, and SAMD7. Each is linked with L2HGDH in more than 1 cancer types. Because this analysis shows association rather than direction, both L2HGDH-to-partner and partner-to-L2HGDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFX4 grouped by L2HGDH-low versus L2HGDH-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L2HGDH→partner) and Y-score (partner→L2HGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RFX4 →	+0.046	+3.766	<.001	.004	3	1
LARGE_INTESTINE	OR10W1 →	+0.016	+3.977	<.001	.001	3	1
LARGE_INTESTINE	SAMD7 →	+0.017	+3.878	<.001	.003	3	1
BLOOD_Leukemia	OPN1LW →	+0.042	+5.539	<.001	.003	3	1
BLOOD_Leukemia	ACTRT1 →	+0.028	+5.201	<.001	.006	3	1
BLOOD_Leukemia	AMELX →	+0.038	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

RFX4 by L2HGDH expression — LARGE_INTESTINE

Explore this box plot interactively →