L1TD1

Across TCGA patient cohorts, L1TD1 mutation is significantly associated with the RNA expression of many other genes, with 5,372 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible L1TD1-associated genes across cancer lineages are FAM138D, TRGV11, and RN7SL470P. Each is linked with L1TD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both L1TD1-to-partner and partner-to-L1TD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM138D grouped by L1TD1-low versus L1TD1-high in OV.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L1TD1→partner) and Y-score (partner→L1TD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FAM138D →	+0.039	+5.215	<.001	.007	3	2
CESC	TRGV11 →	+0.153	+3.996	<.001	.005	3	2
READ	RN7SL470P →	+0.198	+5.653	<.001	.003	3	2
READ	BPNT2P →	+0.148	+6.681	<.001	<.001	3	2
HNSC	HSPD1P18 →	+0.135	+5.241	<.001	.007	3	2
HNSC	NBEAP5 →	+0.178	+5.505	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,372 associations by consensus.

FAM138D by L1TD1 expression — OV

Explore this box plot interactively →