L1TD1

Across TCGA pan-cancer cohorts, L1TD1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of L1TD1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where L1TD1 RNA is repressed in tumor relative to normal tissue. In most cancer types L1TD1 is over-expressed in tumor, although a few such as LUAD and THCA show the opposite, repressed pattern.

LUAD, THCA, and KICH are the cancer types where L1TD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in L1TD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−1.181	<.001	9	view →
THCA	Male	All	−0.567	<.001	9	view →
KICH	All	All	−0.216	<.001	7	view →
LUSC	Female	II,III,IV	−1.232	<.001	5	view →
PRAD	All	All	−0.166	.005	2	view →
CHOL	All	All	+0.277	.035	1	view →
KIRC	Male	All	+0.085	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

L1TD1–LUAD

Open the LUAD breakdown →