L1TD1

Across TCGA patient cohorts, L1TD1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible L1TD1-associated genes across cancer lineages are ATM, EGFR_pY1173, and p90 RSK. Each is linked with L1TD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both L1TD1-to-partner and partner-to-L1TD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by L1TD1-low versus L1TD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L1TD1→partner) and Y-score (partner→L1TD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.425	-1.353	.002	.015	3	2
SKCM	EGFR_pY1173 →	+0.098	+3.012	.002	<.001	3	2
SKCM	p90 RSK →	+0.212	+1.807	.003	.024	3	2
UCEC	eIF4G →	+0.231	+3.459	.018	.005	3	1
UCEC	MEK1 →	+0.424	+3.906	<.001	<.001	3	1
UCEC	MSH2 →	-0.208	-1.388	.004	.041	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ATM by L1TD1 expression — UCEC

Explore this box plot interactively →