L1TD1

Across TCGA cell cohorts, L1TD1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible L1TD1-associated genes across cancer lineages are SLC22A8, CCR8, and MYL10. Each is linked with L1TD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both L1TD1-to-partner and partner-to-L1TD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC22A8 grouped by L1TD1-low versus L1TD1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L1TD1→partner) and Y-score (partner→L1TD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SLC22A8 →	+0.877	+4.044	<.001	.009	3	2
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1
LUNG_SCLC	MYL10 →	+0.117	+4.523	<.001	.003	3	1
LUNG_SCLC	SPATA22 →	+1.215	+4.817	<.001	.001	3	1
LUNG_SCLC	LILRA4 →	+0.133	+4.817	<.001	.001	3	1
BLOOD_Lymphoma	KCNK18 →	+0.019	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

SLC22A8 by L1TD1 expression — LUNG_SCLC

Explore this box plot interactively →