Across TCGA cell cohorts, L1CAM mutation is significantly associated with the RNA expression of many other genes, with 607 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible L1CAM-associated genes across cancer lineages are FOXE3, P2RX2, and KHDC3L. Each is linked with L1CAM in more than 1 cancer types. Because this analysis shows association rather than direction, both L1CAM-to-partner and partner-to-L1CAM results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (L1CAM→partner) and Y-score (partner→L1CAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FOXE3 →	+0.114	+3.328	<.001	.009	3	2
BLOOD_Leukemia	P2RX2 →	+0.073	+3.350	.005	.007	3	2
BLOOD_Leukemia	KHDC3L →	+0.175	+3.359	<.001	.001	3	2
BLOOD_Leukemia	EFCAB7 →	+0.811	+3.120	<.001	.009	3	2
BLOOD_Leukemia	USP17L7 →	+0.067	+2.697	.002	.008	3	2
BLOOD_Leukemia	TRABD2B →	+0.068	+2.556	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 607 associations by consensus.

Exploration

L1CAM survival (RNA) · tumor vs normal (RNA) · all L1CAM data types