KYNU

Across TCGA patient cohorts, KYNU protein abundance is significantly associated with the RNA expression of many other genes, with 17,419 significant associations in total. GBM shows the largest number of these associations.

The most reproducible KYNU-associated genes across cancer lineages are CD86, CD2, and PTPN22. Each is linked with KYNU in more than 7 cancer types. Because this analysis shows association rather than direction, both KYNU-to-partner and partner-to-KYNU results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KYNU versus CD86 in GBM, with a Pearson correlation of 0.76.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KYNU→partner) and Y-score (partner→KYNU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CD86 →	+1.195	+0.727	<.001	<.001	3	8
OV	CD2 →	+1.643	+0.757	<.001	<.001	3	8
GBM	PTPN22 →	+0.989	+0.719	<.001	<.001	3	8
OV	LCP1 →	+1.444	+0.775	<.001	<.001	3	8
OV	AIM2 →	+1.280	+0.713	<.001	<.001	3	8
GBM	TLR8 →	+1.181	+0.729	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,419 associations by consensus.

KYNU vs CD86 — GBM

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