KYNU

Across TCGA pan-cancer cohorts, KYNU RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of KYNU’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KYNU RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KYNU is over-expressed in tumor, although a few such as LIHC and CHOL show the opposite, repressed pattern.

HNSC, COAD, and KIRC are the cancer types where KYNU tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KYNU RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+1.586	<.001	12	view →
COAD	All	II,III,IV	+0.352	<.001	7	view →
KIRC	Male	II,III,IV	+0.410	.012	5	view →
BLCA	Male	III,IV	+1.248	.015	3	view →
LIHC	Female	All	−0.790	.007	3	view →
STAD	All	All	+0.741	.002	3	view →
CHOL	All	II,III,IV	−2.190	.018	2	view →
READ	Male	All	+1.693	.028	2	view →
LUAD	All	All	+0.476	.018	2	view →
ESCA	All	All	+1.117	.028	1	view →
KICH	Male	All	+0.621	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

KYNU–HNSC

Open the HNSC breakdown →