KYNU

Across TCGA patient cohorts, KYNU mutation is significantly associated with the RNA expression of many other genes, with 3,605 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KYNU-associated genes across cancer lineages are EME1, HESX1, and TCF3. Each is linked with KYNU in more than 2 cancer types. Because this analysis shows association rather than direction, both KYNU-to-partner and partner-to-KYNU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EME1 grouped by KYNU-low versus KYNU-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KYNU→partner) and Y-score (partner→KYNU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EME1 →	+0.565	+2.010	.001	.001	3	3
UCEC	HESX1 →	+0.601	+2.928	<.001	<.001	3	3
UCEC	TCF3 →	+0.703	+2.946	<.001	<.001	3	3
UCEC	NUFIP1 →	+0.675	+2.895	<.001	<.001	3	3
LUAD	PARP2 →	+0.585	+3.222	.003	.009	3	3
UCEC	MAP3K4-AS1 →	+0.756	+3.108	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,605 associations by consensus.

EME1 by KYNU expression — UCEC

Explore this box plot interactively →