KYNU

Across TCGA cell cohorts, KYNU RNA expression is significantly associated with the go_rna of many other GO terms, with 4,208 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KYNU-associated GO terms across cancer lineages are Quinolinate biosynthetic process, Cytoplasmic pattern recognition receptor signaling pathway, and L-kynurenine catabolic process. Each is linked with KYNU in more than 16 cancer types. Because this analysis shows association rather than direction, both KYNU-to-partner and partner-to-KYNU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Quinolinate biosynthetic process grouped by KYNU-low versus KYNU-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KYNU→partner) and Y-score (partner→KYNU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Quinolinate biosynthetic process →	+2.005	+4.193	<.001	<.001	3	17
LIVER	Cytoplasmic pattern recognition receptor signaling pathway →	+0.089	+3.153	.001	.005	3	10
SKIN	L-kynurenine catabolic process →	+1.262	+3.167	<.001	<.001	3	9
OESOPHAGUS	Quinolinate metabolic process →	+1.639	+2.991	<.001	<.001	3	9
CNS	Zymogen activation →	+0.151	+1.979	<.001	.001	3	9
SKIN	Kynurenine metabolic process →	+0.826	+3.504	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,208 associations by consensus.

Quinolinate biosynthetic process by KYNU expression — LUNG_NSCLC_LUAD

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