KYNU

Across TCGA cell cohorts, KYNU mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KYNU-associated genes across cancer lineages are TAFA1, SPRR3, and TEX55. Each is linked with KYNU in more than 1 cancer types. Because this analysis shows association rather than direction, both KYNU-to-partner and partner-to-KYNU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAFA1 grouped by KYNU-low versus KYNU-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KYNU→partner) and Y-score (partner→KYNU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TAFA1 →	+0.239	+3.103	.001	.004	3	2
SOFT_TISSUE	SPRR3 →	+0.061	+4.930	<.001	.008	3	1
SOFT_TISSUE	TEX55 →	+0.026	+5.369	<.001	.004	3	1
SOFT_TISSUE	GP9 →	+0.026	+5.977	<.001	.001	3	1
SOFT_TISSUE	OR10K1 →	+0.006	+5.977	<.001	.001	3	1
SOFT_TISSUE	OR1C1 →	+0.088	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

TAFA1 by KYNU expression — LARGE_INTESTINE

Explore this box plot interactively →