KYAT1

Across TCGA patient cohorts, KYAT1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KYAT1-associated genes across cancer lineages are ERK2, eIF4E, and GAPDH. Each is linked with KYAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KYAT1-to-partner and partner-to-KYAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by KYAT1-low versus KYAT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KYAT1→partner) and Y-score (partner→KYAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.219	+2.906	.007	.001	3	2
UCEC	eIF4E →	+0.194	+2.820	.030	.035	3	1
UCEC	GAPDH →	+0.488	+3.169	.032	.018	3	1
UCEC	Heregulin →	-0.142	-3.308	.006	.009	3	1
UCEC	IGFBP2 →	-0.684	-3.169	.013	.019	3	1
UCEC	Ku80 →	+0.314	+1.713	.001	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ERK2 by KYAT1 expression — UCEC

Explore this box plot interactively →