KY

Across TCGA patient cohorts, KY mutation is significantly associated with the RNA expression of many other genes, with 4,220 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KY-associated genes across cancer lineages are MAD2L1, HYOU1, and ABHD3. Each is linked with KY in more than 3 cancer types. Because this analysis shows association rather than direction, both KY-to-partner and partner-to-KY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAD2L1 grouped by KY-low versus KY-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KY→partner) and Y-score (partner→KY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAD2L1 →	+0.728	+1.545	<.001	.005	3	4
UCEC	HYOU1 →	+0.635	+2.186	<.001	.001	3	3
UCEC	ABHD3 →	+0.574	+2.069	<.001	<.001	3	3
UCEC	HSPA4L →	+0.700	+3.711	<.001	<.001	3	3
UCEC	SIRT6 →	+0.346	+2.069	<.001	<.001	3	3
UCEC	LSM10 →	+0.409	+2.754	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,220 associations by consensus.

MAD2L1 by KY expression — UCEC

Explore this box plot interactively →