KY

Across TCGA pan-cancer cohorts, KY RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated KY data layer compared with 5 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher KY RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KY expression acts as an unfavorable survival marker, although some lineages such as KIRP and PRAD show a favorable association.

UVM, SKCM, and COAD are the cancer types where KY RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	II,III,IV	0.344	0.677	.006	47	view →
SKCM	OS	Quartile	II,III,IV	0.229	0.425	.004	35	view →
COAD	DFS	Median	IV	0.204	0.478	.001	28	view →
LIHC	OS	Median	III,IV	0.188	0.455	.001	28	view →
LUAD	DFS	Quartile	III,IV	0.472	0.763	.005	27	view →
CESC	DFS	Median	All	0.402	0.659	.002	22	view →
KIRP	DFS	Quartile	III,IV	1.000	0.199	.011	21	view →
LUSC	OS	Median	All	0.334	0.464	.012	18	view →
PRAD	DFS	Median	All	0.865	0.705	.004	18	view →
HNSC	DFS	Median	All	0.575	0.737	.006	18	view →
UCEC	DFS	Quartile	All	0.856	0.934	.007	10	view →
SCLC	DFS	Median	IV	0.151	0.548	.032	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

KY–UVM (DFS)

Open the UVM breakdown →