KY

Across TCGA cell cohorts, KY mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible KY-associated genes across cancer lineages are ZC2HC1B, ETV3L, and MYOCOS. Each is linked with KY in more than 1 cancer types. Because this analysis shows association rather than direction, both KY-to-partner and partner-to-KY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZC2HC1B grouped by KY-low versus KY-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KY→partner) and Y-score (partner→KY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ZC2HC1B →	+0.054	+3.584	.001	.008	3	1
OESOPHAGUS	ETV3L →	+0.006	+3.857	<.001	.002	3	1
OESOPHAGUS	MYOCOS →	+0.015	+4.115	<.001	.001	3	1
SOFT_TISSUE	IFNA13 →	+0.072	+4.930	<.001	.008	3	1
SKIN	MS4A6E →	+0.054	+4.415	<.001	.007	3	1
BLOOD_Leukemia	OR10T2 →	+0.647	+4.276	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ZC2HC1B by KY expression — OESOPHAGUS

Explore this box plot interactively →