KRTAP9-4

Across TCGA cell cohorts, KRTAP9-4 mutation is significantly associated with the mutation status of many other genes, with 191 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KRTAP9-4-associated genes across cancer lineages are NLN, TAS1R2, and RAD54B. Each is linked with KRTAP9-4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP9-4-to-partner and partner-to-KRTAP9-4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NLN grouped by KRTAP9-4-low versus KRTAP9-4-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP9-4→partner) and Y-score (partner→KRTAP9-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NLN →	+5.502	+5.502	.003	.003	1	2
LUNG_SCLC	TAS1R2 →	+4.502	+5.066	.007	.007	1	2
LUNG_SCLC	RAD54B →	+5.502	+5.502	.003	.003	1	2
LUNG_SCLC	OR5R1 →	+4.502	+5.066	.007	.007	1	1
LUNG_SCLC	CWH43 →	+4.502	+5.066	.007	.007	1	1
LUNG_SCLC	GPR63 →	+5.502	+5.502	.003	.003	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 191 associations by consensus.

NLN by KRTAP9-4 expression — LUNG_SCLC

Explore this box plot interactively →