KRTAP8-2P

Across TCGA pan-cancer cohorts, KRTAP8-2P RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated KRTAP8-2P data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KRTAP8-2P RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KRTAP8-2P expression acts as an unfavorable survival marker, although some lineages such as ESCA and PAAD show a favorable association.

HNSC, COAD, and ESCA are the cancer types where KRTAP8-2P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.321	0.701	<.001	117	view →
COAD	OS	Tertile	All	0.133	0.806	<.001	45	view →
ESCA	DFS	Tertile	III,IV	1.000	0.373	.011	36	view →
BLCA	OS	Tertile	IV	0.132	0.615	<.001	36	view →
PAAD	DFS	Tertile	All	0.629	0.211	.012	30	view →
UVM	OS	Tertile	All	0.220	0.917	<.001	27	view →
BRCA	DFS	Tertile	II,III,IV	0.791	0.893	.023	18	view →
TGCT	DFS	Tertile	II,III,IV	0.621	0.949	.034	18	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →
SKCM	DFS	Tertile	III,IV	0.381	0.620	.037	9	view →
MESO	OS	Quartile	II,III,IV	0.259	0.422	.023	3	view →
SARC	OS	Tertile	All	0.750	0.834	.048	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

KRTAP8-2P–HNSC (DFS)

Open the HNSC breakdown →