Across TCGA pan-cancer cohorts, KRTAP8-1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated KRTAP8-1 data layer compared with 11 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher KRTAP8-1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated KRTAP8-1 expression acts as an unfavorable survival marker.

CESC and STAD are the cancer types where KRTAP8-1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.146	0.740	<.001	12	view →
STAD	DFS	Median	All	0.211	0.709	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: KRTAP8-1 tumor-vs-normal RNA expression · all KRTAP8-1 data types