Across TCGA pan-cancer cohorts, KRTAP8-1 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of KRTAP8-1’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where KRTAP8-1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KRTAP8-1 is over-expressed in tumor.
LUSC are the cancer types where KRTAP8-1 tumor–normal differential expression is most reproducible.