KRTAP7-1

Across TCGA pan-cancer cohorts, KRTAP7-1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated KRTAP7-1 data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KRTAP7-1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KRTAP7-1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and LUAD show a favorable association.

HNSC, PAAD, and UVM are the cancer types where KRTAP7-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.163	0.380	.008	81	view →
PAAD	DFS	Tertile	All	0.642	0.231	<.001	48	view →
UVM	OS	Quartile	All	0.407	0.735	.003	36	view →
UCS	OS	Tertile	IV	0.206	0.781	.010	30	view →
UCEC	DFS	Tertile	II,III,IV	0.576	0.752	.031	30	view →
LUAD	OS	Tertile	All	0.708	0.332	.025	21	view →
SCLC	DFS	Tertile	III,IV	0.137	0.546	.042	18	view →
PCPG	DFS	Tertile	All	0.733	0.921	.001	18	view →
LUSC	OS	Tertile	III,IV	0.212	0.432	.032	12	view →
COAD	OS	Tertile	III,IV	0.206	0.702	.017	9	view →
LGG	DFS	Tertile	All	0.643	0.766	.004	9	view →
ACC	OS	Tertile	II,III,IV	0.268	0.788	.028	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

KRTAP7-1–HNSC (DFS)

Open the HNSC breakdown →