Across TCGA pan-cancer cohorts, KRTAP7-1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of KRTAP7-1’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where KRTAP7-1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KRTAP7-1 is over-expressed in tumor.
LUSC, KIRC, and LIHC are the cancer types where KRTAP7-1 tumor–normal differential expression is most reproducible.