KRTAP5-8

Across TCGA pan-cancer cohorts, KRTAP5-8 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated KRTAP5-8 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher KRTAP5-8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KRTAP5-8 expression acts as an unfavorable survival marker.

SKCM and LUAD are the cancer types where KRTAP5-8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	II,III,IV	0.138	0.846	<.001	19	view →
LUAD	OS	Median	All	0.228	0.788	.003	18	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

KRTAP5-8–SKCM (OS)

Open the SKCM breakdown →