Across TCGA pan-cancer cohorts, KRTAP5-11 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated KRTAP5-11 data layer compared with 4 for mutation status.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KRTAP5-11 RNA is associated with better overall survival. In most high-consensus cancer types, elevated KRTAP5-11 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.
HNSC, ACC, and READ are the cancer types where KRTAP5-11 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.