KRTAP4-7

Across TCGA patient cohorts, KRTAP4-7 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP4-7-associated genes across cancer lineages are EGFR_pY1068, MEK1, and Di-Ras3. Each is linked with KRTAP4-7 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP4-7-to-partner and partner-to-KRTAP4-7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by KRTAP4-7-low versus KRTAP4-7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP4-7→partner) and Y-score (partner→KRTAP4-7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.326	-3.000	.024	.037	3	2
UCEC	MEK1 →	+0.418	+3.000	.048	.037	2	1
UCEC	Di-Ras3 →	-0.228	-3.000	.007	.037	2	1
UCEC	A-Raf_pS299 →	-0.155	-3.000	.025	.037	1	1
UCEC	p62 Lck ligand →	+0.519	+3.000	.005	.037	1	1
UCEC	Tuberin →	+0.421	+3.000	.006	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

EGFR_pY1068 by KRTAP4-7 expression — UCEC

Explore this box plot interactively →