KRTAP4-4

Across TCGA patient cohorts, KRTAP4-4 mutation is significantly associated with the RNA expression of many other genes, with 122 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP4-4-associated genes across cancer lineages are CYP4A44P, RNU6-166P, and RPS3AP23. Each is linked with KRTAP4-4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP4-4-to-partner and partner-to-KRTAP4-4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYP4A44P grouped by KRTAP4-4-low versus KRTAP4-4-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP4-4→partner) and Y-score (partner→KRTAP4-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	CYP4A44P →	+0.251	+4.973	<.001	.009	3	2
PRAD	RNU6-166P →	+0.708	+7.939	<.001	.008	3	2
SKCM	RPS3AP23 →	+0.047	+4.614	<.001	.006	3	2
SKCM	HMGB1P29 →	+0.236	+4.265	<.001	.003	3	2
UCEC	DAZL →	+0.109	+4.178	.001	.001	3	1
BLCA	GPHB5 →	+0.134	+5.411	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 122 associations by consensus.

CYP4A44P by KRTAP4-4 expression — BLCA

Explore this box plot interactively →