KRTAP4-4

Across TCGA cell cohorts, KRTAP4-4 mutation is significantly associated with the mutation status of many other genes, with 181 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KRTAP4-4-associated genes across cancer lineages are ZNHIT2, LMAN2L, and FHL1. Each is linked with KRTAP4-4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP4-4-to-partner and partner-to-KRTAP4-4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNHIT2 grouped by KRTAP4-4-low versus KRTAP4-4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP4-4→partner) and Y-score (partner→KRTAP4-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNHIT2 →	+4.523	+5.087	.006	.006	1	2
LARGE_INTESTINE	LMAN2L →	+5.523	+5.523	.003	.003	1	2
LARGE_INTESTINE	FHL1 →	+4.523	+5.087	.006	.006	1	1
LARGE_INTESTINE	SLC39A9 →	+4.523	+5.087	.006	.006	1	1
LARGE_INTESTINE	UTS2 →	+4.523	+5.087	.006	.006	1	1
LARGE_INTESTINE	STYK1 →	+4.523	+5.087	.006	.006	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 181 associations by consensus.

ZNHIT2 by KRTAP4-4 expression — LARGE_INTESTINE

Explore this box plot interactively →