KRTAP4-16

Across TCGA cell cohorts, KRTAP4-16 mutation is significantly associated with the mutation status of many other genes, with 225 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KRTAP4-16-associated genes across cancer lineages are RGSL1, KRT40, and HDAC11. Each is linked with KRTAP4-16 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP4-16-to-partner and partner-to-KRTAP4-16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RGSL1 grouped by KRTAP4-16-low versus KRTAP4-16-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP4-16→partner) and Y-score (partner→KRTAP4-16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RGSL1 →	+6.044	+6.044	.001	.001	1	2
SOFT_TISSUE	KRT40 →	+4.502	+5.066	.007	.007	1	2
LARGE_INTESTINE	HDAC11 →	+5.087	+4.523	.006	.006	1	2
CNS	PTX4 →	+6.044	+6.044	.001	.001	1	1
CNS	HLA-G →	+4.044	+5.000	.008	.008	1	1
LARGE_INTESTINE	PEG10 →	+5.087	+4.523	.006	.006	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 225 associations by consensus.

RGSL1 by KRTAP4-16 expression — CNS

Explore this box plot interactively →