Across TCGA patient cohorts, KRTAP4-12 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP4-12-associated genes across cancer lineages are MEK1, Notch1, and STAT3_pY705. Each is linked with KRTAP4-12 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP4-12-to-partner and partner-to-KRTAP4-12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP4-12→partner) and Y-score (partner→KRTAP4-12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.590	+3.000	.005	.037	1	1
UCEC	Notch1 →	+0.188	+3.000	.021	.037	1	1
UCEC	STAT3_pY705 →	-0.430	-3.000	.004	.037	1	1
UCEC	C-Raf →	+0.201	+3.000	.015	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

KRTAP4-12 survival (RNA) · tumor vs normal (RNA) · all KRTAP4-12 data types