KRTAP25-1

Across TCGA cell cohorts, KRTAP25-1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. CNS shows the largest number of these associations.

The most reproducible KRTAP25-1-associated genes across cancer lineages are OR4D2, SLC35G3, and TBC1D21. Each is linked with KRTAP25-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP25-1-to-partner and partner-to-KRTAP25-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4D2 grouped by KRTAP25-1-low versus KRTAP25-1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP25-1→partner) and Y-score (partner→KRTAP25-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR4D2 →	+0.019	+5.029	<.001	.006	3	1
LARGE_INTESTINE	SLC35G3 →	+0.011	+4.467	<.001	.004	3	1
LARGE_INTESTINE	TBC1D21 →	+0.015	+5.022	<.001	.002	3	1
LARGE_INTESTINE	PYDC2 →	+0.108	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR6Q1 →	+0.022	+5.022	<.001	.002	3	1
LARGE_INTESTINE	CD300H →	+0.033	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

OR4D2 by KRTAP25-1 expression — LUNG_SCLC

Explore this box plot interactively →