KRTAP21-4P

Across TCGA pan-cancer cohorts, KRTAP21-4P RNA is linked to patient survival in 7 of 34 cancer types, making it the most broadly survival-associated KRTAP21-4P data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KRTAP21-4P RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KRTAP21-4P expression acts as an unfavorable survival marker, although some lineages such as ESCA and SKCM show a favorable association.

HNSC, THCA, and BLCA are the cancer types where KRTAP21-4P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.001	0.712	<.001	72	view →
THCA	DFS	Tertile	II,III,IV	0.415	0.911	<.001	63	view →
BLCA	OS	Tertile	IV	0.051	0.600	<.001	45	view →
PAAD	OS	Tertile	II,III,IV	0.100	0.586	<.001	36	view →
LUAD	DFS	Tertile	All	0.287	0.813	.002	27	view →
ESCA	DFS	Tertile	III,IV	0.569	0.260	.013	18	view →
SKCM	DFS	Tertile	II,III,IV	0.812	0.245	.021	15	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

KRTAP21-4P–HNSC (OS)

Open the HNSC breakdown →