Across TCGA pan-cancer cohorts, KRTAP2-2 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KRTAP2-2 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher KRTAP2-2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KRTAP2-2 expression acts as an unfavorable survival marker.

COAD, UCEC, and SCLC are the cancer types where KRTAP2-2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.111	0.871	<.001	24	view →
UCEC	OS	Median	III,IV	0.061	0.588	.018	12	view →
SCLC	OS	Median	II,III,IV	0.152	0.777	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: KRTAP2-2 tumor-vs-normal RNA expression · all KRTAP2-2 data types