Across TCGA pan-cancer cohorts, KRTAP2-2 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of KRTAP2-2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where KRTAP2-2 RNA is repressed in tumor relative to normal tissue. In most cancer types KRTAP2-2 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

KIRC and BRCA are the cancer types where KRTAP2-2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRTAP2-2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	−0.019	<.001	6	view →
BRCA	All	II,III,IV	+0.014	.016	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: KRTAP2-2 RNA expression & survival · all KRTAP2-2 data types