KRTAP11-1

Across TCGA pan-cancer cohorts, KRTAP11-1 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated KRTAP11-1 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KRTAP11-1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KRTAP11-1 expression acts as an unfavorable survival marker.

HNSC, ESCA, and CESC are the cancer types where KRTAP11-1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.215	0.664	<.001	54	view →
ESCA	OS	Median	II,III,IV	0.186	0.707	<.001	33	view →
CESC	OS	Median	III,IV	0.191	0.667	.009	18	view →
LGG	OS	Median	All	0.134	0.811	<.001	12	view →
ACC	OS	Median	All	0.188	0.820	<.001	12	view →
UCEC	OS	Median	IV	0.133	0.754	<.001	12	view →
LIHC	DFS	Median	All	0.049	0.556	<.001	12	view →
COAD	OS	Median	III,IV	0.140	0.691	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

KRTAP11-1–HNSC (OS)

Open the HNSC breakdown →